Does Baking Soda Kill Mice? 5 Important Things to Know Before Using It

Written by Kirstin Harrington
Published: November 7, 2023
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Do you have a mouse problem in your home? You may have read that baking soda can take care of these pesky rodents. While baking soda alone isn’t likely to kill mice, there are plenty of things you can use to get the job done. 

Here’s what you need to know about how to use baking soda to repel mice and helpful prevention methods that work wonders! 

Can You Use Baking Soda to Kill Mice? 

baking soda

Mice will avoid baking soda unless it’s mixed with something they find enticing.

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Many blog posts will tell you that baking soda can kill mice. This kitchen staple has bicarbonate which has an adverse reaction with a mouse’s stomach acid. When the two mix it creates carbon dioxide.

This gas quickly builds up within the rodent’s digestive system, causing a fatal blockage. Here’s the issue: mice won’t just walk up to a mound of baking soda and start snacking. In order to effectively use baking soda to kill mice, it has to be mixed with something they find appetizing. 

You can mix baking soda with peanut butter, roll it into balls, and place them where you believe the mice are around your home. You could also mix together baking soda, flour, and sugar into a shallow bowl. 

Lastly, mice like chocolate as much as people do! Put some cocoa powder and baking soda in a dish before sprinkling in a bit of sugar. Place this mixture in your home and the mice will quickly consume it

How to Get Rid of Mice

Now that you know how you can use baking soda to kill mice, what other methods are there to try? Here are a handful of things around your home that can help you with any rodent issues you may be facing. 

1. Artificial Sweetener

Natural sweetener sorbitol is poured from the cup. Selective focus, closeup.

Artificial sweetener lures mice in because they love anything sweet!


If you’re in this game for the long haul, consider using aspartame. This is an affordable way to kill mice, even though artificial sweetener is safe for humans to consume. For mice, aspartame is toxic to the microbes in their digestive tract.

To use this to rid your home of mice, take a single packet of artificial sweetener and mix it with a dollop of peanut butter. Roll it into a ball and place it around your house. This sweet and nutty mixture will be impossible for mice to resist. 

You’ll need patience, as it takes a bit of time for aspartame to work. 

2. Instant Mashed Potato

Mashed Potatoes with Melted Butter

Adding a small water dish next to the potato flakes can help get rid of mice quicker.

©Fudio/iStock via Getty Images

Speaking of artificial sweeteners, the next method is to use a non-toxic method to poison mice for pet owners. The last thing you want is for Fido to eat a peanut butter ball containing xylitol. 

All you need for this is a bit of mashed potato powder to get the job done. As the mice snack on this mixture, their stomachs will fill and they’ll quickly become parched. 

When they begin to drink, the dry potato flakes will expand in their stomach. This can kill the mice instantly. You can combine artificial sweeteners and potato flakes to entice these rodents even more. 

3. Cement Powder

construction worker pouring cement or concrete with pump tube. Reinforced steel bars and rods

Cement powder will become a solid once it mixes with the liquid in a mouse’s digestive system.


You may have to head out to your garage for this next one. To use cement mix to kill a mouse, you can combine it with food they find appealing. As stated earlier, some of their favorites are peanut butter and cocoa powder. 

We advise pet owners to skip this method, as we can’t guarantee your furry friend won’t try to eat this deadly mixture. For those without pets, place the cement and food combo in areas where mice frequent

As they consume what they believe is a tasty treat, the cement powder will harden as the digestive juices make contact. It’s safe to say no mouse will survive this! 

4. Vitamin D-3

Close up cropped image millennial mixed race girl holding pill and glass of fresh water, taking medicine from head ache, stomach pain or taking vitamins, sedation meds, healthcare concept

You can use a tablet or capsule of Vitamin D to kill mice.


The majority of people need to take Vitamin D due to deficiencies, but what about mice? Well, active ingredients such as cholecalciferol act as poison to these pesky rodents! Calcium and phosphorus levels will rise in their body after a mouse consumes Vitamin D. 

This eventually leads to a myriad of issues including kidney failure, internal bleeding, and heart problems. One 5,000 IU tablet can take care of an entire mischief of mice. Grab your trusty peanut butter and crush a single tablet of Vitamin D-3. 

Roll into small balls and place them strategically around your home. Children, dogs, and cats can have adverse reactions to Vitamin D-3. Please avoid this method if you have pets or children.

5. Ultrasonic Devices

Four-striped grass mouse

Some ultrasonic mouse repellants are at such a high frequency, domestic animals won’t even hear it!

© Prosicky

If you don’t want to break open a fresh box of baking soda or mess with cement powder, there is another humane way to get rid of mice. Consider using an ultrasonic device that you plug into a wall.

These contraptions release an extremely high frequency that humans cannot hear. Rodents of all types will quickly want to flee the area where the frequency is coming from. It’s important to keep in mind that dogs and cats may get irritated if the frequency is audible to them. 

Summary of Ways to Deter Mice

RankNatural Mice Deterrent
IntroBaking Soda and peanut butter, flour, sugar, or cocoa powder.
1. Artificial sweetener
2.Mashed potato flakes 
3.Cement powder
4.Vitamin D-3
5.Ultrasonic devices

The photo featured at the top of this post is © Image Source/DigitalVision via Getty Images

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About the Author

Kirstin is a writer at A-Z Animals primarily covering animals, news topics, fun places, and helpful tips. Kirstin has been writing on a variety of topics for over five years. She has her real estate license, along with an associates degree in another field. A resident of Minnesota, Kirstin treats her two cats (Spook and Finlay) like the children they are. She never misses an opportunity to explore a thrift store with a coffee in hand, especially if it’s a cold autumn day!

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