Credelio for Dogs: Risks, Side Effects, Dosage, and More

Written by Angie Menjivar
Updated: January 16, 2024
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Flea bites aren’t just itchy, uncomfortable, and potentially dangerous. They can also wreak havoc on your doggo’s skin in the form of allergy dermatitis. But there’s something you can do to keep your pup safe. By working with your vet to determine which medicine is best to treat flea and tick infestations, you can do a world of good for your favorite and ever-faithful canine. Learn about Credelio for dogs, including why they may need it, what the proper dosage is depending on weight, and what side effects you should be aware of!

Credelio for Dogs: Risks, Side Effects, Dosage, and More

When Do Dogs Need Credelio?

Flea Control

The presence of fleas on your pup’s skin and fur isn’t just a nuisance for them — it becomes a whole family problem! Getting control of flea infestations requires serious effort along with the right medicine. When you’re dealing with an infestation, you have to move quickly and Credelio is the type of medicine that comes to the rescue, bringing you and your pup much-needed relief.

Tick Control

Ticks aren’t just gross to look at and pick off your dog’s skin, they can also carry a host of dangerous bacteria that can result in serious conditions, including Lyme disease. Credelio provides your pup with the protection it needs not just from fleas, but also from those pesky ticks, including the dangerous ones that transmit diseases. In dogs with thick coats, it’s hard to spot ticks. Using a medication like Credelio offers protection for your dog and peace of mind for you.

Skin Protection

dog with fleas

Credelio can keep your pup’s skin from getting irritated because it clears flea infestations.

© ThamKC/Shutterstock.com

Since flea infestations can result in flea allergy dermatitis (FAD), the use of Credelio also helps to prevent this skin condition from developing. Without fleas biting at your dog’s skin, you don’t have to worry about your pup having to deal with this uncomfortable allergic reaction.

Side Effects of Credelio for Dogs

Gastrointestinal Upset

Most pups tolerate Credelio well with little to no side effects. However, some pups are more sensitive to medications and may experience side effects like gastrointestinal upset. This may include vomiting or diarrhea after administration. Keep an eye on your pup if this occurs — symptoms should resolve on their own shortly after.

Loss of Appetite

Your dog may also experience a loss of appetite. But don’t worry, this side effect doesn’t last long. They may want to skip dinner, but they should be back to their usual selves, devouring whatever you put in their food bowl the next morning (if not sooner!).

Increased Thirst

Make sure to have plenty of fresh water out for your pup when you administer Credelio. The medication may cause increased thirst, also called polydipsia, in some dogs. Let them lap up water to keep hydrated and comfortable.

Lethargy

Some dogs get a bit sleepy and lethargic. If that’s the case, skip the walk and let your pup rest and recover. This side effect, like others in this list, doesn’t occur in all dogs. However, when it does, it typically subsides quickly. If you notice lingering symptoms, don’t hesitate to check with your vet for a professional opinion.

Signs of Credelio Overdose or Allergies in Dogs

Vomiting

The active ingredient in Credelio is lotilaner, which some dogs may be allergic to. If your dog is allergic or if there is an overdose of the medication, vomiting may occur. Work with your veterinarian to determine if Credelio is appropriate for your pup to prevent any adverse effects.

Diarrhea

A young woman reacts to stinky dog

Credelio is generally well tolerated but your pup may experience diarrhea after administration.

©UfaBizPhoto/Shutterstock.com

Overdose or allergic reactions to Credelio may also result in diarrhea. If you suspect your dog may have gotten into the medication and taken more than the recommended dosage, take it to your nearest emergency veterinary hospital for treatment or contact an animal poison control center.

Muscle Tremors

Another more serious sign of overdose or allergy to Credelio is muscle tremors. This response requires immediate veterinary care. After administration of this or any medication, keep a close eye on your pup to act quickly should unusual symptoms occur.

Loss of Coordination

Your pup may develop an abnormal gait or start suddenly bumping into walls or furniture. If you notice your pup has lost coordination, they could have overdosed on the medication. They may also be having an allergic reaction. Typically, these symptoms show up alongside others, so be sure to take note of anything unusual you’ve witnessed to provide a full recap to your vet.

Seizures

In more severe cases of overdose or allergic reactions, seizures may result. Prevent accidental overdose by securing this medication in an area your dog can’t reach. Additionally, always consult with your veterinarian before administering this or any other medication.

Credelio Risks to Consider

Overdose

Generally, Credelio is a safe medication. However, when it is used improperly, adverse events could occur, especially as the dosage ingested gets higher. Select a secure location in your home where you can store all medications away from curious, mischievous paws. Keeping medications secure can prevent accidental overdoses. Additionally, keep track of when you administer medications, so you don’t forget and accidentally administer more than recommended.

Allergies

Close-up view of tick on human finger against dog lying in grass.

Although Credelio is fantastic for controlling flea and tick infestations, if your pup is allergic to its active ingredient, you may need to consider alternatives.

©Jaromir Chalabala/Shutterstock.com

Some dogs are allergic to lotilaner, the active ingredient in Credelio. This medication requires a prescription from your veterinarian — when you request it, have them review your pup’s medical history to determine if Credelio is the right choice. So long as your vet green-lights the medication, you and your pup should be good to go. However, if this is the first time you’re administering Credelio, stay near your pup for 24 hours to monitor any changes in behavior.

When Is Credelio Not an Option for Your Dog?

Dogs with diagnosed neurologic conditions, such as seizures, may not be the best candidates for Credelio. Lotilaner is an isoxazoline so you should discuss with your veterinarian if Credelio is safe for your pup. As of now, there are no known drug interactions with Credelio. However, you should be forthright with your veterinarian about any supplements or other medications your pup may be taking before administering Credelio.

Credelio Dosage Chart

When you administer Credelio, provide your pup with some food as well. Do not administer on an empty stomach. Your pup only needs a single chewable tablet per month. You can start during any month of the year and continue each month for years to come to ensure flea and tick prevention. The minimum weight for dogs taking Credelio is 4.4 pounds. Before administering this medication to puppies, they must be eight weeks or older.

WeightLotilaner ContentChewable Tablet (Monthly)
4.4 – 6 pounds56.25 mg1
6.1 – 12 pounds112.5 mg1
12.1 – 25 pounds225 mg1
25.1 – 50 pounds450 mg1
50.1 – 100 pounds900 mg1
Over 100 poundsAppropriate comboAppropriate combo

Alternatives to Credelio

Credelio isn’t the only flea and tick medication on the market. You have some alternative options to select from that include Bravecto, Frontline, NexGard, Simparica, Advantix, Comfortis, and Sentinel Spectrum Chews. You might also try some natural alternatives to help repel fleas and ticks. Though natural remedies may be helpful, they may not be potent enough to get rid of an existing flea and tick infestation. Nevertheless, some pet parents use neem oil, diluted essential oils, lemon juice, diatomaceous earth, and even apple cider vinegar to discourage parasites from infesting pets and homes.  

The photo featured at the top of this post is © iStock.com/Cunaplus_M.Faba

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About the Author

Angie Menjivar is a writer at A-Z-Animals primarily covering pets, wildlife, and the human spirit. She has 14 years of experience, holds a Bachelor's degree in psychology, and continues her studies into human behavior, working as a copywriter in the mental health space. She resides in North Carolina, where she's fallen in love with thunderstorms and uses them as an excuse to get extra cuddles from her three cats.

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