These Are the Best Enzyme Cleaners for Cat Urine (Ranked!) in 2022

Written by Joan W.
Published: April 16, 2022

This post may contain affiliate links to our partners like Chewy, Amazon, and others. Purchasing through these helps us further the A-Z Animals mission to educate about the world's species..

Unlike dogs, cats don’t have to be potty trained. If you make a clean litter box available, even kittens will use it.

Cats are often called fastidious, and they are. A healthy, happy cat who is not marking its territory and is not under stress will use the litter box or go outside 100% of the time.

Unfortunately, there are still many reasons your cat might pee inside the house. They may be telling you they are sick, under stress, or that the litter box is inconvenient to use or too dirty. They may be marking their territory. 

Regardless, once your cat has peed, the best thing you can do is get rid of the smell, so they don’t make a habit of using that spot. As you probably know, cat pee has an intense odor that is made to last.

Fortunately, enzyme cleaners break down the molecules of cat urine and remove the smell – even for your cat’s super-sensitive nose. Here, we updated our 2022 reviews to bring you the most effective products in today’s market.

A-Z-Animals Top Picks for Enzyme Cleaners for Cat Urine

  1. Simple Solution Pet Urine Destroyer
  2. Simple Solution Pet Urine Destroyer
    • Approved by the Carpets and Rug Institute
    • Do not cause discoloration
    • Comes with an easy-pour cap
    • Safe for pets
    Check Chewy Check Amazon
  3. Emmy's Best Pet Products Enzyme-Based Pet Odor & Stain Eraser
  4. Emmy's Best Pet Products Enzyme-Based Pet Odor & Stain Eraser
    • Safe on carpet, tile, wood, leather, and fabric
    • Recommended for small animal cages
    • Lavender scent
    • Money-back guarantee
    Check Chewy Check Amazon
  5. Nature's Miracle Cat Enzymatic Stain & Odor Remover
  6. Nature's Miracle Cat Enzymatic Stain & Odor Remover
    • Specifically designed for cats
    • Light citrus scent
    • Remove cat urine stains
    • Multi-surface cleaner
    Check Chewy Check Amazon
  7. Urine Off Cat & Kitten Formula
  8. Urine Off Cat & Kitten Formula
    • Non-toxic formula
    • Safe to use around people and pets
    • USDA Certified Biobased Product
    • Remove urine odor and stains
    Check Chewy Check Amazon
  9. Nature's Miracle Deep Cleaning Carpet Shampoo
  10. Nature's Miracle Deep Cleaning Carpet Shampoo
    • For use with steam cleaner or carpet cleaning machine
    • Lift even deep-set stains
    • Professional strength formula
    • Restore original color
    Check Chewy Check Amazon

1. Overall Best: Simple Solution Pet Urine Destroyer

In our review, the overall best enzyme cleaner for cat urine is Simple Solution Pet Urine Destroyer for its effectiveness on tough urine stains.

Approved by the Carpets and Rug Institute, Simple Solution is designed for use on carpets, upholstery, bedding, fabric toys, clothing, and any water-safe surface without causing discoloration.

Enzyme solutions include bacteria that produce enzymes that break down the urine or vomit molecules enough that the bacteria can eat them. By removing the odor at a molecular level rather than covering it up, you discourage your pet from marking the same spot repeatedly.

This solution features an easy-pour cap for direct application on your carpet or furniture or refilling spray bottles. It is safe to use around your pets as long as you follow the directions.

Overall Best
Simple Solution Pet Urine Destroyer
  • Approved by the Carpets and Rug Institute
  • Do not cause discoloration
  • Comes with an easy-pour cap
  • Safe for pets
Check Chewy Check Amazon

2. Best Scented Cleaner: Emmy’s Best Pet Products Enzyme-Based Pet Odor & Stain Eraser

Emmy’s Best Pet Products are made in the USA and are safe on carpet, tile, wood, leather, and fabric. It also works as a laundry additive when cleaning towels and bedding.

In addition to eliminating cat urine smells, the enzymes fight odor from feces, vomit, or any organic odors. It’s also recommended for small animal cages, crates, and kennels. 

Use it on carpets, flooring, laundry, closets, or anywhere your cats or other pets hang out. The solution uses enzymes to remove odors and leaves behind a lavender scent. It comes with a money-back guarantee.

Best Scented Cleaner
Emmy's Best Pet Products Enzyme-Based Pet Odor & Stain Eraser
  • Safe on carpet, tile, wood, leather, and fabric
  • Recommended for small animal cages
  • Lavender scent
  • Money-back guarantee
Check Chewy Check Amazon

3. Best Cleaner Targeted for Cats: Nature’s Miracle Cat Enzymatic Stain & Odor Remover

Nature’s Miracle has been around for 35 years and makes several enzyme cleaner products, but the Cat Enzymatic Stain & Odor Remover is specifically for cats. It’s designed to be safe to use around your cats and features a light citrus scent.

You can use it to remove cat urine stains on carpets, hard floors, furniture, and fabrics. It also works on feces, vomit, drool, and other organic odors and stains.

Best Cleaner Targeted for Cats
Nature's Miracle Cat Enzymatic Stain & Odor Remover
  • Specifically designed for cats
  • Light citrus scent
  • Remove cat urine stains
  • Multi-surface cleaner
Check Chewy Check Amazon

4. Best Biobased Product: Urine Off Cat & Kitten Formula

Urine Off is a non-toxic formula that directly targets cat and kitten urine. Use it to remove stains and odors from carpets, rugs, and household surfaces. It’s safe to use around people and pets when used as directed.

Made in the USA, Urine Off is a USDA Certified Biobased Product (74% biobased) that is approved by Carpet Rug Institute. It is designed to completely and permanently remove urine stains and smells.

Best Biobased Product
Urine Off Cat & Kitten Formula
  • Non-toxic formula
  • Safe to use around people and pets
  • USDA Certified Biobased Product
  • Remove urine odor and stains
Check Chewy Check Amazon

5. Best for Carpet Cleaning Machines: Nature’s Miracle Deep Cleaning Carpet Shampoo

Use Nature’s Miracle Deep Cleaning Carpet Shampoo with a steam cleaner or carpet cleaning machine. It is designed to help you clean the deep urine or other organic pet stains, odors, and allergens to restore and brighten your carpet and furniture.

This formula penetrates deep into the carpet and upholstery fibers to lift even deep-set stains. The low foaming formula can be used with any steam cleaner or the carpet cleaning machine.

Best for Carpet Cleaning Machines
Nature's Miracle Deep Cleaning Carpet Shampoo
  • For use with steam cleaner or carpet cleaning machine
  • Lift even deep-set stains
  • Professional strength formula
  • Restore original color
Check Chewy Check Amazon

Choosing the Best: What to Look For

When choosing the best enzyme cleaners for cat urine, there are two key factors you will want to consider. Most importantly, make sure it’s really an enzyme cleaner. You don’t want a chemical cleaner that will just try and mask the odor. 

Make sure any product you buy uses enzymes and isn’t a chemical mask. Enzyme cleaners actually break down and destroy the urine molecules. 

Cats have a more developed sense of smell than we do. Masking products may fool us, but your cat will still recognize the smell and may continue to mark that spot.

The second important factor is the concentration of enzymes in the bottle. The concentration of enzymes is not listed on the bottle, but we targeted brands with a high percentage of positive reviews because successful results are evidence of active enzymes. The fewer enzymes in the bottle, the more applications it will take to see results.

Enzyme Cleaners for Cat Urine: Pros and Cons Compared

The PROS of enzymes cleaners for cat urine include:

  • They are safe and effective cleaners for removing organic stains like urine, feces, vomit, and blood. 
  • They also work well on food stains and can clean even tricky stains, like wine and oil.
  • Enzyme cleaners do not contain harmful chemicals and are safe to use around pets.

The CONS of enzymes cleaners for cat urine include:

  • They can eat away at some surfaces if used too often, such as the grout between tiles or painted surfaces.
  • It can work slowly. It’s a process with live bacteria and, especially if the concentration of enzymes is low, may take some time to deliver the desired result.
  • You may need to reapply the solution every 24 hours until it’s completely gone.

Verified Review: User Experience

Reviewers rave that the Simple Solution pet urine destroyer obliterates stains and odor from cat and dog urine. Many users say it works on laundry as well as carpet and furniture. Most reviewers give it five stars. 

Emmy’s Best Pet Products enzyme-based pet odor and stain eraser eliminate smell and stain for cat urine and vomit. Most users like the scent but say it works better on fresh stains than old ones.

Most users say Nature’s Miracle Cat enzymatic stain and odor remover effectively takes away the stain and odor. A few did not see the desired effect, but others say you need to use it as instructed.

Urine Off Cat and Kitten Formula amazed users with how well it removed odors and stains and how quickly it worked. Old stains may need to be soaked for a while and covered in plastic to get the desired deep-clean result.

According to users, nature’s Miracle Deep Cleaning Carpet Shampoo gets the odor and stains out. Reviewers also say it can be used as a spray. They point out you need a steam or carpet cleaning machine if you’re going to use it to clean the carpet.

About the Author

Joan Weisman is an experienced freelance marketing strategist and copywriter who helps small businesses expand their audience and stay top of mind with customers. She loves animals and dotes on her cat and dog.

Thank you for reading! Have some feedback for us? Contact the AZ Animals editorial team.