Simethicone Dosage Chart for Dogs: Uses, Risks, Side Effects, and More

Written by Drew Wood
Published: October 25, 2023
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Simethicone is an over-the-counter medication for bloating, burping, flatulence, and pain caused by intestinal gas in dogs or cats. It can be a safe and effective treatment for these common problems. Before treating your animal with any medication, knowing the risks, side effects, proper dosage, and other essential factors is important. This article provides basic information to help you speak knowledgeably with your veterinarian about your dog’s condition and medication.

Professional veterinarians examining dog in clinic, closeup

Even though Simethicone is available over the counter, it’s best to consult your veterinarian first.

©New Africa/

Why Do Dogs Get Gas?

Dog with a pumkin

Feeding your dog pumpkin can be a natural way to help prevent gas.


Before discussing how to treat gas in dogs, it’s helpful to know what causes it so you can help prevent it. Some breeds are more subject to gas than others. Dogs with flat faces, like Pekingese, tend to ingest more air as they eat, which forms gastrointestinal gas bubbles. Gas can form from eating too quickly and ingesting gulps of air along with food. Dogs can get gassy with sudden changes to their diet, eating table scraps or garbage, or because something in their diet doesn’t agree with them.

One of the natural ways to prevent gas is to use a higher-quality dog food. One with probiotics or prebiotics will aid digestion. Pumpkin is a natural food that can help settle your dog’s digestion and balance the acidity in the stomach. Pumpkins should not comprise more than 10% of the animal’s diet. Training your dog to eat more slowly can also help.

What is Simethicone?

You might be familiar with Simethicone under brand names like Alka-Seltzer, Gas-X, Maalox, or Mylanta. These are marketed for humans suffering from intestinal gas. In both humans and animals, this medication doesn’t decrease gas production; it just prevents larger bubbles from forming. Smaller-sized bubbles are less painful and pass more easily through the gastrointestinal tract. The drug may be administered in tablets, chewables, liquids, or capsules.

Why Give Simethicone to a Dog?

how do dogs get parvo

Simethicone can help a dog suffering from gastrointestinal distress.

©Olya Maximenko/

A veterinarian might recommend Simethicone to treat bloating, flatulence and burping together with dietary changes. Another reason a dog might take Simethicone is to clear out bloating before getting an x-ray or gastrointestinal endoscopy to help the vet see the organs without distortion.

Risks and Side Effects of Simethicone

X-ray of dog lateral view red highlight in gastric dilatation volvulus- stomach twists-double bubble pattern indicates stomach torsion has occurred- Veterinary medicine- Veterinary anatomy- blue color

The red highlight in this x-ray indicates gastric dilatation volvulus and severe bloating twisting of the stomach.


It is not absorbed through the digestive system, so it is generally safe, has few side effects, and rarely results in overdoses. However, some dogs have drug allergies or hypersensitivities. Dogs can react to Simethicone with diarrhea, lethargy, nausea, and vomiting. Simethicone is often administered together with antibiotics but may interact with other drugs your dog is taking. Many vets consider this drug safe for a pregnant or lactating dog, but its safety has not been definitively established. Giving a dog unusually large dosages of Simethicone can produce loose stools.

Simethicone will not be enough for a dog suffering from a severe form of bloat called gastric dilatation-volvulus. Symptoms can include unsuccessful vomiting that brings nothing up or just foam or mucus. The dog may be anxious and restless, hunched, panting, breathing shallowly, and foaming at the mouth. The abdomen may or may not be visibly bloated, but if you put your ear to it, you will not hear normal digestion sounds. If you suspect your dog has bloat, give two doses of Simethicone immediately and call your vet immediately.

Dosage for Simethicone for Dogs

big and small dogs

Consult your veterinarian for proper medicine dosages for your dog based on size.


Always consult your veterinarian for expert guidance on the correct medication dosage for your dog. As a general guideline, if you use a liquid that can be precisely measured, administer 1-2 mg per pound of body weight every six to 12 hours as needed. The chart below shows what that could look like for dogs of different weights.

Dog’s Weight (Pounds)Simethicone DosageDog Breeds Include
0 – 5 5-10 mgPomeranian and Chihuahua
5 – 1010-20 mgBoston Terrier and Pekingese
10 – 2020-40 mgWest Highland Terrier and Pembroke Welsh Corgi
20 – 3040-60 mgBeagle and Cardigan Welsh Corgi
30 – 4060-80 mgVizsla and Samoyed
40 – 5080-100 mgIrish Setter and Airedale Terrier
50 – 60100-120 mgLabrador and Golden Retrievers, and Staffordshire Terrier
60 – 70120-140 mgChow Chow, American Staffordshire Terrier, and Dalmatian
70 – 80140-160 mgCane Corso, Rottweiler and Akita
80 – 90160-180 mgChinook, Bloodhound, and German Shepherds
90 – 100 +180-200 mgGreat Dane, Saint Bernard, and Bullmastiff

Monitor your dog closely while taking any medication. Watch for adverse side effects or a worsening of the animal’s condition. Complete the entire medical treatment plan your vet gives, even if the dog seems completely better.

The photo featured at the top of this post is © Miroslava Levina/

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About the Author

Drew Wood is a writer at A-Z Animals focusing on mammals, geography, and world cultures. Drew has worked in research and writing for over 20 years and holds a Masters in Foreign Affairs (1992) and a Doctorate in Religion (2009). A resident of Nebraska, Drew enjoys Brazilian jiu-jitsu, movies, and being an emotional support human to four dogs.

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