The Best Enzyme Cleaners for Cleaning Dog Urine

Written by Marisa Wilson
Published: June 20, 2022

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Enzyme cleaners are an excellent choice for cleaning up dog urine. They are specifically designed to break down the proteins and bacteria that cause stains and smells. The enzymes in the cleaner work to break down these substances, which makes it much easier to remove them. In addition, enzyme cleaners often contain ingredients that help to neutralize odors.

If your dog has an accident indoors, it’s essential to clean the mess up quickly to prevent stains and smells from lingering. Which ones are the best enzyme cleaners on the market? This article will discuss the top 5 best enzyme cleaners for cleaning dog urine stains and smells.

  1. Nature's Miracle Cat & Dog Urine Destroyer Foam Aerosol Sprays
  2. Nature's Miracle Cat & Dog Urine Destroyer Foam Aerosol Sprays
    • Designed to break down dog urine completely as soon as it happens
    • Contains no hazardous ingredients that could harm your pet or home
    • Foam formula allows you to clearly see whether you've covered the urine spot
    • Deodorizes the spot so well that your dog won't go to the bathroom there again
    Check Amazon
  3. KIDS 'N' PETS Instant All-Purpose Stain & Odor Remover
  4. KIDS 'N' PETS Instant All-Purpose Stain & Odor Remover
    • Designed to remove multiple types of stains and odors made by pets and children
    • All-purpose cleaner saves you from purchasing multiple products
    • Can be used on multiple surface types, ding mattresses, in litter boxes, etc.
    • Removes blood, grass, even skunk odor!
    Check Amazon
  5. TriNova Pet Stain & Odor Remover
  6. TriNova Pet Stain & Odor Remover
    • Safe to use around pets
    • Made only with natural ingredients
    • Gentle on carpets, upholstery, and other fabrics
    • Works on a wide range of stains, including urine and vomit
    • Mint-scented
    Check Chewy Check Amazon
  7. Angry Orange Odor Eliminator and Enzyme Carpet Cleaner for Pets Citrus Scented Dog Deodorizing Spray and Urine Stain Remover for Home Use
  8. Angry Orange Odor Eliminator and Enzyme Carpet Cleaner for Pets Citrus Scented Dog Deodorizing Spray and Urine Stain Remover for Home Use
    • Made with safe, natural ingredients
    • Eradicates odors on contact
    • Utilizes enzymes instead of harsh chemicals
    • Works for up to 80 hours
    • Can be used on a variety of surfaces, including carpets, hardwood floors, tile, litter boxes, pillows, kennels, and more
    Check Amazon
  9. Hoover Paws & Claws Deep Cleaning Carpet Shampoo
  10. Hoover Paws & Claws Deep Cleaning Carpet Shampoo
    • Designed to keep carpets cleaner longer by protecting them against future stains
    • Not just for dog messes, it works on wine stains and muddy footprints
    • Formulated to clean large areas with a carpet-cleaning machine
    • Fresh cotton breeze fragrance
    Check Amazon

1. Best Overall: Nature’s Miracle Cat & Dog Urine Destroyer

You know anything with “destroyer” in the name will do an epic job at tackling the worst accidents. Nature’s Miracle is a product designed to break down dog urine as soon as it happens, without leaving any behind. It also doesn’t have any hazardous ingredients that could harm your pet or home. The best thing about this particular formula is it is foam rather than a liquid spray. This can help you see what area of the stain you have covered to ensure you don’t miss any spots that can stain. Another good reason to use this foam cleaner is that it removes the scent well so that the dog never goes back to the bathroom in that area again! It helps both short and long term. When your dog makes the next mess, be ready with this cleaner!

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Best Overall
Nature's Miracle Cat & Dog Urine Destroyer Foam Aerosol Sprays
  • Designed to break down dog urine completely as soon as it happens
  • Contains no hazardous ingredients that could harm your pet or home
  • Foam formula allows you to clearly see whether you've covered the urine spot
  • Deodorizes the spot so well that your dog won't go to the bathroom there again
Check Amazon

2. Best for Parents: KIDS ‘N’ PETS 

If you have kids and dogs, finding a versatile product that works for humans and pets can be challenging. Streamline your whole cleaning routine with this fantastic solution. Since it can be used on many things for many reasons, you won’t need to waste your money on purchasing multiple products. It makes the smell of the dog disappear almost upon contact and removes a ton of different stains. It can take care of blood, grass, and even skunk! Aside from many stains, you can use them on several objects and locations. For example, mattresses, inside cars, and even litter boxes! No matter the situation, this all-purpose cleaner saves the day.

Best for Parents
KIDS 'N' PETS Instant All-Purpose Stain & Odor Remover
  • Designed to remove multiple types of stains and odors made by pets and children
  • All-purpose cleaner saves you from purchasing multiple products
  • Can be used on multiple surface types, ding mattresses, in litter boxes, etc.
  • Removes blood, grass, even skunk odor!
Check Amazon

3. Best for A Gentle Clean: TriNova Pet Stain & Odor Remover

Dog stains are never fun, but they’re an inevitable part of life if you have a furry friend. This stain remover is designed to make things a little easier, and it’s safe for use around pets. Made with only natural ingredients, it’s gentle on carpets and other surfaces like rugs or upholstery. And it works on a wide range of stains, such as urine and vomit, so you can get your home looking clean and fresh again. Best of all, it’s mint-scented, and it can be used to freshen up dog beds or pillows by lightly misting it. If you’re concerned about harsh chemicals, this is the best one to naturally clean dog urine.

Best Gentle Clean
TriNova Pet Stain & Odor Remover
  • Safe to use around pets
  • Made only with natural ingredients
  • Gentle on carpets, upholstery, and other fabrics
  • Works on a wide range of stains, including urine and vomit
  • Mint-scented
Check Chewy Check Amazon

4. Best for Multi-Surfaces: Angry Orange Enzyme Cleaner

This potent formula can quickly and effectively tackle even the most stubborn pet stains and odors. The harsh chemicals used in cleaning pet urine and feces can often leave colors that are impossible to remove and cause health problems for animals and humans. Today, there are many commercial cleaners on the market which claim to be able to eliminate these smells. However, they still contain ingredients that can potentially harm your pets and the material itself. Unlike other pet cleaners that mask foul odors, this formula eradicates them with enzymes that activate upon contact. And it keeps working for up to 80 hours, so your home will stay fresh and clean all day long. This safe and versatile cleaner can be used on various surfaces, including carpet, hardwood floors, tile, litter boxes, pillows, kennels, etc. Plus, it’s made with natural ingredients and is safe for both dogs and cats. 

Best for Multi-Surfaces
Angry Orange Odor Eliminator and Enzyme Carpet Cleaner for Pets Citrus Scented Dog Deodorizing Spray and Urine Stain Remover for Home Use
  • Made with safe, natural ingredients
  • Eradicates odors on contact
  • Utilizes enzymes instead of harsh chemicals
  • Works for up to 80 hours
  • Can be used on a variety of surfaces, including carpets, hardwood floors, tile, litter boxes, pillows, kennels, and more
Check Amazon

5. Best for Large Areas: Hoover Paws & Claws Deep Cleaning Carpet Shampoo

It’s designed to help keep your carpets cleaner for longer by protecting them against future stains. And it’s not just for dog messes – it can also help with things like wine spills and muddy footprints. After cleaning, the product continues to work, ensuring the best results are achieved. Stain sprays are good for when you catch the accidents as they happen and for spot treatments, but sometimes you need to deep clean all your carpet where your pet likes to sleep or play. It’s far more efficient to clean large areas with a carpet cleaning machine. This formula works excellent in cleaning machines like the Rug Doctor shampooers. The cotton breeze scent will make your cleaning more noticeable and rewarding.

Best for Large Areas
Hoover Paws & Claws Deep Cleaning Carpet Shampoo
  • Designed to keep carpets cleaner longer by protecting them against future stains
  • Not just for dog messes, it works on wine stains and muddy footprints
  • Formulated to clean large areas with a carpet-cleaning machine
  • Fresh cotton breeze fragrance
Check Amazon

Choosing the Best: What to Look for

When looking for a cleaner to clean up urine stains it’s essential to make sure it has enzymes. Enzymes help break down and altogether remove the urine. You will also want to check if it’s safe for your pet or kids. Not everything made to clean pet messes up is safe for pets. Check the scents on the description to ensure it’s one you’ll like.

Another thing to consider is how you want to use the product. If you’re going to use a shampooer, make sure it’s compatible with the machine you’ll be using. Some solutions are made only for spots and not machines unless otherwise noted. Alternatively, if you need to clean up stains on your carpet or furniture. You can look at reviews or find articles that research for you, such as this one.  

The Different Types of Enzyme Cleaners: Pros and Cons

There are a few types of enzyme cleaners. Each type has a different purpose. The kinds of enzyme cleaners are:

  • Spot cleaner: used to deep treat small spots
  • Foam Cleaner: works like spot cleaners but is made with foam 
  • Shampooer solution: made for cleaning machines for large areas like carpets
  • Wipes: for on-the-go messes 
  • Natural: doesn’t use chemicals and is gentler 

Enzyme cleaners have several pros and a fair share of cons. You should factor them both in when making your purchase. So, which is the right cleaner for you? That all depends on your needs. To help you make an informed decision, we’ve put together a handy chart comparing the pros and cons of enzyme cleaners. Now you can see for yourself what these cleaners are all about! 

Nature’s Miracle Cat & Dog Urine Destroyer

ProsCons
Removes sticky residueLong time to dry
Tackles strong urineStrong smell
Cleans deep into the carpetN/A

KIDS ‘N’ PETS 

ProsCons
Immediate differenceUnscented 
Kid-safeN/A
All-purpose cleanerN/A

TriNova Pet Stain & Odor Remover

ProsCons
Natural ingredients Strong scent
Kid-safe The spray straw is too short 
Doesn’t stainN/A

Angry Orange Enzyme Cleaner

ProsCons
Lasting scentLong dry time
Removers odors permanently Doesn’t keep dogs from peeing again 
Safe for smell sensitivities N/A

Hoover Paws & Claws Deep Cleaning Carpet Shampoo

ProsCons
Great for large areasNot suitable for severe accidents 
Handles multiple stainsN/A
Odor removal N/A

Verified Review: User Experience 

If you like the smell of a great scent after you’re done cleaning then the Angry Orange cleaner is for you. One review said, “First of all, the scent of this is phenomenal. It’s not subtle, but it’s fresh and non-chemical.” Several reviews mentioned how unique and long-lasting the scent last.

Kids ‘N’ Pets can tackle anything. Old stains are no match for this. One user said, “I love this product – I used it on a cat pee stain (which has been on a guest mattress for six months – not used). I finally got around to cleaning it, and this product worked like a charm.” It’s not too late to get rid of those worn-in odors!

About the Author

Creepy-crawly creatures enthrall Marisa. Aside from raising caterpillars, she has a collection of spiders as pets. The brown recluse is her favorite spider of all time. They're just misunderstood. You don't have to worry about squishing the creatures as her catching, and relocating abilities can safely move stray centipedes or snakes to a new location that's not your living room.

The Best Enzyme Cleaners for Cleaning Dog Urine FAQs (Frequently Asked Questions) 

Why do dogs pee in the same spot?

When they pee in the same area, the urine is never entirely removed, and they can still smell it. If this happens to you, you might need to switch cleaners.

Can some cleaners lighten my carpet?

Yes, some can lighten or discolor the carpet, so it’s essential to do a patch test on your carpet where it’s unnoticeable.