Bladder stones, also called uroliths and cystic calculi, are a serious and painful condition that occurs in many animals, including guinea pigs. The stones are the buildup of tiny crystals of calcium oxalate, uric acid, and calcium phosphate that become lodged in the bladder (where urine is stored) or the urethra (from which urine is expelled from the body). If you suspect your guinea pig might have bladder stones, it’s important to seek treatment. Continue reading to learn everything you need to know about the causes, symptoms, diagnosis, and treatment of bladder stones in guinea pigs.
Causes of Bladder Stones

Some guinea pigs are born with a genetic predisposition for developing bladder stones.
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Several factors determine if your guinea pig will develop bladder stones. Too much calcium oxalate in the diet (a common component of spinach, parsley, and strawberries) may contribute to the buildup of crystals. Genetic factors also appear to significantly increase the risk of bladder stones, meaning some pigs are more likely to develop stones than others. A history of poor urinary health may also contribute to the presence of bladder stones in your guinea pig.
How these factors influence each other is still a bit of a mystery, but regardless of the risk factors, bladder stones develop in the same way each time. As the risk factors compound, small minerals and proteins form tiny crystals in the bladder, which then develop into one or more stones.
Symptoms of Bladder Stones

If your guinea pig is exhibiting symptoms of bladder stones, it’s important to seek professional treatment.
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Your guinea pig may begin to experience abdominal pain, which manifests as sensitivity to touch in the affected area. Changes in urination patterns, either going more frequently or ceasing to urinate, are common symptoms indicative of bladder stones. Blood in the urine is also a sign of stones. Urinary tract infections are associated with bladder stones.
While the stone is forming, you may not notice any specific changes in your pet, but once it begins to really develop, the stone can become painful and serious. The worst possible scenario is for the stone to become lodged in the urethra. This can lead to acute kidney failure, sepsis, and hyperkalemia (elevated blood potassium levels), resulting in death. Knowing the signs and keeping a close eye on your guinea pig can help avoid poor prognoses.
How Bladder Stones Are Diagnosed and Treated

Providing prompt treatment gives your guinea pig the best chance of recovery.
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If your guinea pig is experiencing symptoms of a bladder stone, the first step is to contact your vet immediately. They will examine your pig, including getting a urinalysis and an X-ray. Urinalysis can identify the presence of crystals, along with blood or signs of a bacterial infection in the urine. while an X-ray or ultrasound determines the composition and location of the stone.
Bladder stones are among the trickier medical conditions to properly treat in a guinea pig. Bladder stones in guinea pigs cannot be dissolved by medication, and if left untreated, they will become progressively worse over time. When the stone is still quite small, it might be flushed out naturally with increased water intake. A low-calcium diet, medication, or other tips prescribed by your vet may prevent the stone from growing. If a urinary tract infection is encouraging the growth of the stone, then your vet will prescribe antibiotics. When the stone is too large to be passed naturally, surgical removal is the standard and recommended treatment.
Avoiding Bladder Stones

It is very important that the guinea pig has access to clean water at all times.
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Bladder stones are a tricky condition, often going unnoticed until they have already begun to form. However, you can take steps to avoid the condition in your pet. The most important thing is your guinea pig’s diet. Avoid frequent feeding of high-calcium and high-oxalate foods, and focus on providing a balanced diet with mostly hay and a variety of fresh vegetables. Forego dietary supplements except for those recommended by your vet. In most cases, the nutrients obtained from a normal diet should be sufficient.
Don’t neglect your guinea pig’s urinary health. Provide plenty of clean drinking water at all times to encourage regular, healthy urination. Cages with more than one pig may require multiple water bottles, since one pig may tend to dominate a single water bottle. Replacing your guinea pig’s bedding weekly discourages the growth of the bacteria associated with urinary tract infections and the development of bladder stones. Trimming the hairs around the anus can further limit bacterial growth.